HIST4H4

已知的結構

直系同源搜索: PDBe RCSB

PDBID列表

4H9O、3WKJ、3AYW、3WA9、5B0Z、5AVB、2CV5、5AV5、3AV2、3WTP、3AV1、3AZK、3X1V、5AV8、1F66、4QUU、3CFS、4YYK、4QUT、3NQJ、3A6N、3W99、5AVC、2RS9、3F9Z、3QZT、3QBY、3W97、4M38、4YM6、3CFV、4HGA、1EQZ、2RJE、3QZV、1HQ3、4H9P、3AZL、3AFA、1TZY、3UVY、5CPK、3JPX、4U9W、4N3W、4YYJ、4YYD、4H9N、4H9R、3AZI、4LD9、3UVX、3AZH、5BNX、4N4F、1U35、4YYG、3O36、2ARO、5AV9、4H9S、3AZF、3W98、4GQB、4H9Q、5BNV、3WAA、3AZG、3AZE、2RNY、1ZKK、2QQS、2LVM、3X1T、3AN2、2KWO、3QZS、3F9W、5FFW、5CPJ、3F9X、3IJ1、4YM5、3AZJ、4YY6、3AZN、2IG0、4YYH、4YYI、5CPI、3W96、3R45、2KWN、3F9Y、5AV6、3AZM、5BO0、3X1S、4QYD、4KGC、3UVW、4YYN、3X1U、3UW9、2F8N、3NQU、5B0Y、4YYM、5C3I、4Z5T、5B24、5FA5、4Z2M、5E5A、5FWE、5B2I、5B40、5B2J、5JA4、5AY8、4ZUX

識別號

别名

H4-16；, H4/p, histone cluster 4, H4, histone cluster 4 H4, HIST4H4, H4 histone 16, H4C5, H4C4, H4C9, H4C12, H4C3, H4C13, H4C11, H4C1, H4C14, H4C15, H4C8, H4C6, H4C2, H4C16

外部ID

OMIM：615069 MGI：2448432 HomoloGene：134468 GeneCards：H4-16

基因位置（人类）

染色体	12號染色體^[1]

基因座	12p12.3	起始	14,767,999 bp^[1]
基因座	12p12.3	终止	14,771,131 bp^[1]

基因位置（小鼠）

染色体	小鼠13号染色体^[2]

基因座	13\|13 A3.1	起始	22,224,806 bp^[2]
基因座	13\|13 A3.1	终止	22,225,532 bp^[2]

基因本體
分子功能	• protein domain specific binding • 血浆蛋白结合 • protein heterodimerization activity • DNA结合 • histone binding • RNA binding
細胞組分	• 膜 • 染色体 • 核质 • 細胞外區域 • nuclear chromosome • 核小體 • 外排體 • 细胞核 • 细胞外间质 • 大分子复合体
生物學過程	• telomere organization • epigenetic maintenance of chromatin in transcription-competent conformation • protein heterotetramerization • negative regulation of megakaryocyte differentiation • CENP-A containing chromatin assembly • DNA replication-dependent chromatin assembly • rDNA heterochromatin assembly • negative regulation of gene expression, epigenetic • DNA-templated transcription, initiation • double-strand break repair via nonhomologous end joining • beta-catenin-TCF complex assembly • telomere capping • nucleosome assembly • regulation of gene silencing by miRNA • regulation of megakaryocyte differentiation • regulation of hematopoietic stem cell differentiation
Sources:Amigo / QuickGO

直系同源

物種

人類

小鼠

Entrez


121504


319158

Ensembl


ENSG00000197837


ENSMUSG00000060639

UniProt


P62805


P62806

mRNA序列


NM_175054


NM_175656

蛋白序列

NP_003537 NP_003486 NP_003535 NP_003539 NP_003531
NP_003536

NP_291074 NP_783587 NP_783588 NP_835499 NP_835500
NP_001182350 NP_835515 NP_783585 NP_783586 NP_835582 NP_835583 NP_783583 NP_694813

基因位置（UCSC）

Chr 12: 14.77 – 14.77 Mb

Chr 13: 22.22 – 22.23 Mb

PubMed查找

^[3]

^[4]

維基數據

檢視/編輯人類

檢視/編輯小鼠

HIST4H4爲人體中的一種編碼一類組蛋白H4的基因^[5]。HIST4H4沒有內含子，編碼組蛋白H4家族中的一種蛋白質。HIST4H4基因對應的mRNA缺乏Poly(A)尾巴。不過，這類mRNA有一個回文終止元件^[6]。

參考

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000197837 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000060639 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ. The human and mouse replication-dependent histone genes. Genomics. Oct 2002, 80 (5): 487–98. PMID 12408966. doi:10.1016/S0888-7543(02)96850-3.
^ Entrez Gene: HIST4H4 histone cluster 4, H4. （原始内容存档于2019-10-17）.

拓展閱讀

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