CXCL5

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Hemokin (C-X-C motiv) ligand 5
Identifikatori
SimboliCXCL5; ENA-78; SCYB5
Vanjski IDOMIM: 600324 HomoloGene: 88672 GeneCards: CXCL5 Gene
Ontologija gena
Molekularna funkcija • aktivnost hemokina
Celularna komponenta • ekstracelularni region
• ekstracelularni prostor
Biološki proces • hemotaksa
• inflamatorni odgovor
• immune response
• transdukcija signala
• interćelijska signalizacija
• pozitivna regulacija ćelijske proliferacije
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez6374n/a
EnsemblENSG00000163735n/a
UniProtP42830n/a
RefSeq (mRNA)NM_002994n/a
RefSeq (protein)NP_002985n/a
Lokacija (UCSC)Chr 4:
75.08 - 75.08 Mb		n/a
PubMed pretraga[1]n/a

CXCL5, hemokin (C-X-C motiv) ligand 5 protein je kod ljudi kodiran CXCL5 genom.[1][2] CXCL5 protein je mali citokin iz CXC hemokin familije koji je takođe poznat kao epitelijalni neutrofil-aktivirajući peptid 78 (ENA-78). On se proizvodi nakon stimulacije ćelija sa inflamatornim citokinima interleukin-1 ili faktorom nekroze tumora-alfa.[3] CXCL5 ekspresija je takođe bila primećena u eosinofilima, i ona može biti inhibirana sa tip II interferonom IFN-γ.[4] Ovaj hemokin stimuliše hemotaksu neutrofila koji poseduje angiogene osobine. On pobuđuje te efekte putem interakcije sa hemokin receptorom CXCR2 na ćelijskoj površini.[4] CXCL5 gen je kodiran na četiri eksona. On je lociran na ljudskom hromozomu 4 zajedno sa nekoliko drugih CXC hemokin gena.[3][5] CXCL5 je bio impliciran u remodelovanje veznog tkiva.[4][6]

Reference

  1. ↑ Chang MS, McNinch J, Basu R, Simonet S (Nov 1994). „Cloning and characterization of the human neutrophil-activating peptide (ENA-78) gene”. J Biol Chem 269 (41): 25277–82. PMID 7929219. 
  2. ↑ „Entrez Gene: CXCL5 chemokine (C-X-C motif) ligand 5”. 
  3. ↑ 3,0 3,1 Chang MS, McNinch J, Basu R, Simonet S (1994). „Cloning and characterization of the human neutrophil-activating peptide (ENA-78) gene”. J. Biol. Chem. 269 (41): 25277–82. PMID 7929219. Arhivirano iz originala na datum 2007-03-13. Pristupljeno 2014-05-24. 
  4. ↑ 4,0 4,1 4,2 Persson T, Monsef N, Andersson P, Bjartell A, Malm J, Calafat J, Egesten A (2003). „Expression of the neutrophil-activating CXC chemokine ENA-78/CXCL5 by human eosinophils”. Clin. Exp. Allergy 33 (4): 531–7. DOI:10.1046/j.1365-2222.2003.01609.x. PMID 12680872. 
  5. ↑ O'Donovan N, Galvin M, Morgan JG (1999). „Physical mapping of the CXC chemokine locus on human chromosome 4”. Cytogenet. Cell Genet. 84 (1-2): 39–42. DOI:10.1159/000015209. PMID 10343098. 
  6. ↑ Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5. 

Dodatna literatura

  • Duchene J, Lecomte F, Ahmed S, Cayla C, Pesquero J, Bader M, Perretti M, Ahluwalia A (2007). „A novel inflammatory pathway involved in leukocyte recruitment: role for the kinin B1 receptor and the chemokine CXCL5.”. J. Immunol. 179 (7): 4849–56. PMID 17878384. 
  • Walz A, Schmutz P, Mueller C, Schnyder-Candrian S (1997). „Regulation and function of the CXC chemokine ENA-78 in monocytes and its role in disease.”. J. Leukoc. Biol. 62 (5): 604–11. PMID 9365115. 
  • Struyf S, Proost P, Van Damme J (2004). „Regulation of the immune response by the interaction of chemokines and proteases.”. Adv. Immunol. 81: 1–44. DOI:10.1016/S0065-2776(03)81001-5. PMID 14711052. 
  • Walz A, Burgener R, Car B, et al. (1992). „Structure and neutrophil-activating properties of a novel inflammatory peptide (ENA-78) with homology to interleukin 8.”. J. Exp. Med. 174 (6): 1355–62. DOI:10.1084/jem.174.6.1355. PMC 2119025. PMID 1744577. 
  • Power CA, Furness RB, Brawand C, Wells TN (1995). „Cloning of a full-length cDNA encoding the neutrophil-activating peptide ENA-78 from human platelets.”. Gene 151 (1-2): 333–4. DOI:10.1016/0378-1119(94)90682-3. PMID 7828901. 
  • Corbett MS, Schmitt I, Riess O, Walz A (1995). „Characterization of the gene for human neutrophil-activating peptide 78 (ENA-78).”. Biochem. Biophys. Res. Commun. 205 (1): 612–7. DOI:10.1006/bbrc.1994.2709. PMID 7999089. 
  • Koch AE, Kunkel SL, Harlow LA, et al. (1994). „Epithelial neutrophil activating peptide-78: a novel chemotactic cytokine for neutrophils in arthritis.”. J. Clin. Invest. 94 (3): 1012–8. DOI:10.1172/JCI117414. PMC 295150. PMID 8083342. 
  • Power CA, Clemetson JM, Clemetson KJ, Wells TN (1996). „Chemokine and chemokine receptor mRNA expression in human platelets.”. Cytokine 7 (6): 479–82. DOI:10.1006/cyto.1995.0065. PMID 8580362. 
  • Ahuja SK, Murphy PM (1996). „The CXC chemokines growth-regulated oncogene (GRO) alpha, GRObeta, GROgamma, neutrophil-activating peptide-2, and epithelial cell-derived neutrophil-activating peptide-78 are potent agonists for the type B, but not the type A, human interleukin-8 receptor.”. J. Biol. Chem. 271 (34): 20545–50. DOI:10.1074/jbc.271.34.20545. PMID 8702798. 
  • Keates S, Keates AC, Mizoguchi E, et al. (1997). „Enterocytes are the primary source of the chemokine ENA-78 in normal colon and ulcerative colitis.”. Am. J. Physiol. 273 (1 Pt 1): G75–82. PMID 9252512. 
  • Wuyts A, Proost P, Lenaerts JP, et al. (1998). „Differential usage of the CXC chemokine receptors 1 and 2 by interleukin-8, granulocyte chemotactic protein-2 and epithelial-cell-derived neutrophil attractant-78.”. Eur. J. Biochem. 255 (1): 67–73. DOI:10.1046/j.1432-1327.1998.2550067.x. PMID 9692902. 
  • Wyrick PB, Knight ST, Paul TR, et al. (1999). „Persistent chlamydial envelope antigens in antibiotic-exposed infected cells trigger neutrophil chemotaxis.”. J. Infect. Dis. 179 (4): 954–66. DOI:10.1086/314676. PMID 10068592. 
  • Wuyts A, Govaerts C, Struyf S, et al. (1999). „Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms.”. Eur. J. Biochem. 260 (2): 421–9. DOI:10.1046/j.1432-1327.1999.00166.x. PMID 10095777. 
  • Hogaboam CM, Bone-Larson CL, Steinhauser ML, et al. (1999). „Novel CXCR2-dependent liver regenerative qualities of ELR-containing CXC chemokines.”. FASEB J. 13 (12): 1565–74. PMID 10463948. 
  • Luu NT, Rainger GE, Nash GB (2000). „Differential ability of exogenous chemotactic agents to disrupt transendothelial migration of flowing neutrophils.”. J. Immunol. 164 (11): 5961–9. PMID 10820279. 
  • Crane IJ, Wallace CA, McKillop-Smith S, Forrester JV (2000). „Control of chemokine production at the blood-retina barrier.”. Immunology 101 (3): 426–33. DOI:10.1046/j.0019-2805.2000.01105.x. PMC 2327097. PMID 11106948. 
  • Zhang C, Thornton MA, Kowalska MA, et al. (2001). „Localization of distal regulatory domains in the megakaryocyte-specific platelet basic protein/platelet factor 4 gene locus.”. Blood 98 (3): 610–7. DOI:10.1182/blood.V98.3.610. PMID 11468158. 
  • Chandrasekar B, Melby PC, Sarau HM, et al. (2003). „Chemokine-cytokine cross-talk. The ELR+ CXC chemokine LIX (CXCL5) amplifies a proinflammatory cytokine response via a phosphatidylinositol 3-kinase-NF-kappa B pathway.”. J. Biol. Chem. 278 (7): 4675–86. DOI:10.1074/jbc.M207006200. PMID 12468547. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 

Spoljašnje veze

  • MeSH Platelet+factor+5
  • p
  • r
  • u
Po familiji
IL-1 superfamilija
1 (1Ra) • 18 • 33
poput IL-6/gp130 koristeći
IL-10 familija
10 • 19 • 20 • 22 • 24 • 26
28 • 29
2/15 • 3 • 4 • 7 • 9 • 13 • 21
IL-12 familija
12 (B) • 23 • 27 • 35
Drugi
5 • 8 • 14 • 16 • 17/25 (A) • 32  • 34
CCL
1 • 2 • 3 • 4 • 5 • 6 • 7 • 8 • 9 • 10 • 11 • 12 • 13 • 14 • 15 • 16 • 17 • 18 • 19 • 20 • 21 • 22 • 23 • 24 • 25 • 26 • 27 • 28
CXCL
1 • 2 • 3 • 4 • 5 • 6 • 7 • 8 • 9 • 10 • 11 • 12 • 13 • 14 • 15 • 16 • 17
CX3CL
XCL
1 • 2
Glavni
TNF (ligand) superfamilija
CD70 • CD153 • CD154
alfa ( Pegilirani 2a, Pegilirani 2b), beta (1a, 1b)
DrugiPo funkciji
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)