Protein-coding gene in the species Homo sapiens
TRIM69 |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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Identifiers |
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Aliases | TRIM69, HSD-34, HSD34, RNF36, Trif, tripartite motif containing 69 |
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External IDs | OMIM: 616017; MGI: 1918178; HomoloGene: 18827; GeneCards: TRIM69; OMA:TRIM69 - orthologs |
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Gene location (Human) |
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![Chromosome 15 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/0/07/Ideogram_human_chromosome_15.svg/300px-Ideogram_human_chromosome_15.svg.png) | Chr. | Chromosome 15 (human)[1] |
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| Band | 15q21.1 | Start | 44,728,988 bp[1] |
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End | 44,767,829 bp[1] |
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Gene location (Mouse) |
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![Chromosome 2 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/b/bb/Ideogram_house_mouse_chromosome_2.svg/260px-Ideogram_house_mouse_chromosome_2.svg.png) | Chr. | Chromosome 2 (mouse)[2] |
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| Band | 2|2 E5 | Start | 121,991,181 bp[2] |
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End | 122,009,508 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - granulocyte
- epithelium of colon
- thymus
- prefrontal cortex
- muscle of thigh
- left testis
- skeletal muscle tissue
- putamen
- left ventricle
- caudate nucleus
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| Top expressed in | - spermatid
- spermatocyte
- seminiferous tubule
- embryo
- embryo
- blastocyst
- morula
- jejunum
- endocrine system
- pancreas
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - protein binding
- metal ion binding
- ubiquitin-protein transferase activity
- transferase activity
| Cellular component | - cytoplasm
- nuclear speck
- nucleus
- cytosol
| Biological process | - protein ubiquitination
- apoptotic process
- protein polyubiquitination
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | |
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ENSG00000278211 ENSG00000185880 |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_182985 NM_001301144 NM_001301145 NM_001301146 NM_080745 |
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RefSeq (protein) | |
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NP_001288073 NP_001288074 NP_001288075 NP_542783 NP_892030 |
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Location (UCSC) | Chr 15: 44.73 – 44.77 Mb | Chr 2: 121.99 – 122.01 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Tripartite motif containing 69 is a protein that in humans is encoded by the TRIM69 gene. [5]
Function
This gene encodes a member of the RING-B-box-coiled-coil (RBCC) family and encodes a protein with an N-terminal RING finger motif, a PRY domain and a C-terminal SPRY domain. The mouse ortholog of this gene is specifically expressed in germ cells at the round spermatid stages during spermatogenesis and, when overexpressed, induces apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described.
References
- ^ a b c ENSG00000185880 GRCh38: Ensembl release 89: ENSG00000278211, ENSG00000185880 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033368 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Tripartite motif containing 69". Retrieved 2016-02-16.
External links
- PDBe-KB provides an overview of all the structure information available in the PDB for Human E3 ubiquitin-protein ligase TRIM69
Further reading
This article incorporates text from the United States National Library of Medicine, which is in the public domain.