TBRG1

Protein-coding gene in the species Homo sapiens
TBRG1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2WZO

Identifiers
AliasesTBRG1, NIAM, TB-5, transforming growth factor beta regulator 1
External IDsOMIM: 610614; MGI: 1100877; HomoloGene: 18102; GeneCards: TBRG1; OMA:TBRG1 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for TBRG1
Genomic location for TBRG1
Band11q24.2Start124,622,836 bp[1]
End124,635,926 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for TBRG1
Genomic location for TBRG1
Band9|9 A4Start37,560,059 bp[2]
End37,568,608 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • granulocyte

  • gastric mucosa

  • rectum

  • monocyte

  • right lung

  • appendix

  • body of pancreas

  • spleen

  • tibia

  • prefrontal cortex
Top expressed in
  • dermis

  • endocardial cushion

  • Gonadal ridge

  • decidua

  • seminal vesicula

  • yolk sac

  • tooth

  • molar

  • migratory enteric neural crest cell

  • skin of external ear
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • nucleus
Biological process
  • DNA replication
  • cell cycle
  • protein stabilization
  • negative regulation of cell population proliferation
  • protein localization to nucleoplasm
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

84897

21376

Ensembl

ENSG00000154144

ENSMUSG00000011114

UniProt

Q3YBR2

Q3UB74

RefSeq (mRNA)

NM_032811

NM_025289

RefSeq (protein)

NP_116200

NP_079565

Location (UCSC)Chr 11: 124.62 – 124.64 MbChr 9: 37.56 – 37.57 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transforming growth factor beta regulator 1 is a protein that in humans is encoded by the TBRG1 gene.[5][6][7]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000154144 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000011114 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Babalola GO, Schultz RM (Oct 1995). "Modulation of gene expression in the preimplantation mouse embryo by TGF-alpha and TGF-beta". Mol Reprod Dev. 41 (2): 133–9. doi:10.1002/mrd.1080410203. PMID 7654366. S2CID 84997218.
  6. ^ Tompkins VS, Hagen J, Frazier AA, Lushnikova T, Fitzgerald MP, di Tommaso A, Ladeveze V, Domann FE, Eischen CM, Quelle DE (Jan 2007). "A novel nuclear interactor of ARF and MDM2 (NIAM) that maintains chromosomal stability". J Biol Chem. 282 (2): 1322–33. doi:10.1074/jbc.M609612200. PMID 17110379.
  7. ^ "Entrez Gene: TBRG1 transforming growth factor beta regulator 1".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
  • Tompkins V, Hagen J, Zediak VP, Quelle DE (2006). "Identification of novel ARF binding proteins by two-hybrid screening". Cell Cycle. 5 (6): 641–6. doi:10.4161/cc.5.6.2560. PMID 16582619.


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