SHMT2 |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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3OU5, 4PVF |
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Identifiers |
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Aliases | SHMT2, GLYA, HEL-S-51e, SHMT, serine hydroxymethyltransferase 2, NEDCASB |
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External IDs | OMIM: 138450; MGI: 1277989; HomoloGene: 133984; GeneCards: SHMT2; OMA:SHMT2 - orthologs |
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Gene location (Human) |
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![Chromosome 12 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/e/e7/Ideogram_human_chromosome_12.svg/300px-Ideogram_human_chromosome_12.svg.png) | Chr. | Chromosome 12 (human)[1] |
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| Band | 12q13.3 | Start | 57,229,573 bp[1] |
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End | 57,234,935 bp[1] |
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Gene location (Mouse) |
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![Chromosome 10 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/4/4e/Ideogram_house_mouse_chromosome_10.svg/260px-Ideogram_house_mouse_chromosome_10.svg.png) | Chr. | Chromosome 10 (mouse)[2] |
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| Band | 10|10 D3 | Start | 127,352,992 bp[2] |
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End | 127,358,313 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - tendon of biceps brachii
- cartilage tissue
- right lobe of liver
- oocyte
- stromal cell of endometrium
- secondary oocyte
- embryo
- body of pancreas
- tibia
- ganglionic eminence
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| Top expressed in | - left lobe of liver
- right kidney
- condyle
- human kidney
- yolk sac
- tail of embryo
- proximal tubule
- internal carotid artery
- somite
- calvaria
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - transferase activity
- amino acid binding
- chromatin binding
- L-allo-threonine aldolase activity
- protein binding
- catalytic activity
- identical protein binding
- glycine hydroxymethyltransferase activity
- pyridoxal phosphate binding
- zinc ion binding
- cobalt ion binding
- serine binding
| Cellular component | - membrane
- BRISC complex
- microtubule cytoskeleton
- mitochondrial intermembrane space
- extracellular exosome
- mitochondrial inner membrane
- cytoplasm
- mitochondrion
- mitochondrial matrix
- mitochondrial nucleoid
- nucleus
| Biological process | - L-serine biosynthetic process
- tetrahydrofolate interconversion
- protein tetramerization
- tetrahydrofolate metabolic process
- protein K63-linked deubiquitination
- folic acid metabolic process
- glycine biosynthetic process from serine
- response to type I interferon
- positive regulation of cell population proliferation
- glycine biosynthetic process
- protein homotetramerization
- one-carbon metabolic process
- glycine metabolic process
- L-serine metabolic process
- regulation of oxidative phosphorylation
- L-serine catabolic process
- regulation of mitochondrial translation
- regulation of aerobic respiration
- cellular response to tetrahydrofolate
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_001166356 NM_001166357 NM_001166358 NM_001166359 NM_005412 |
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RefSeq (protein) | |
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NP_001159828 NP_001159829 NP_001159830 NP_001159831 NP_005403 |
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Location (UCSC) | Chr 12: 57.23 – 57.23 Mb | Chr 10: 127.35 – 127.36 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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