Serine hydroxymethyltransferase 2

Protein-coding gene in the species Homo sapiens
SHMT2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3OU5, 4PVF

Identifiers
AliasesSHMT2, GLYA, HEL-S-51e, SHMT, serine hydroxymethyltransferase 2, NEDCASB
External IDsOMIM: 138450; MGI: 1277989; HomoloGene: 133984; GeneCards: SHMT2; OMA:SHMT2 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for SHMT2
Genomic location for SHMT2
Band12q13.3Start57,229,573 bp[1]
End57,234,935 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for SHMT2
Genomic location for SHMT2
Band10|10 D3Start127,352,992 bp[2]
End127,358,313 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • tendon of biceps brachii

  • cartilage tissue

  • right lobe of liver

  • oocyte

  • stromal cell of endometrium

  • secondary oocyte

  • embryo

  • body of pancreas

  • tibia

  • ganglionic eminence
Top expressed in
  • left lobe of liver

  • right kidney

  • condyle

  • human kidney

  • yolk sac

  • tail of embryo

  • proximal tubule

  • internal carotid artery

  • somite

  • calvaria
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • transferase activity
  • amino acid binding
  • chromatin binding
  • L-allo-threonine aldolase activity
  • protein binding
  • catalytic activity
  • identical protein binding
  • glycine hydroxymethyltransferase activity
  • pyridoxal phosphate binding
  • zinc ion binding
  • cobalt ion binding
  • serine binding
Cellular component
  • membrane
  • BRISC complex
  • microtubule cytoskeleton
  • mitochondrial intermembrane space
  • extracellular exosome
  • mitochondrial inner membrane
  • cytoplasm
  • mitochondrion
  • mitochondrial matrix
  • mitochondrial nucleoid
  • nucleus
Biological process
  • L-serine biosynthetic process
  • tetrahydrofolate interconversion
  • protein tetramerization
  • tetrahydrofolate metabolic process
  • protein K63-linked deubiquitination
  • folic acid metabolic process
  • glycine biosynthetic process from serine
  • response to type I interferon
  • positive regulation of cell population proliferation
  • glycine biosynthetic process
  • protein homotetramerization
  • one-carbon metabolic process
  • glycine metabolic process
  • L-serine metabolic process
  • regulation of oxidative phosphorylation
  • L-serine catabolic process
  • regulation of mitochondrial translation
  • regulation of aerobic respiration
  • cellular response to tetrahydrofolate
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6472

108037

Ensembl

ENSG00000182199

ENSMUSG00000025403

UniProt

P34897

Q9CZN7

RefSeq (mRNA)

NM_001166356
NM_001166357
NM_001166358
NM_001166359
NM_005412

NM_001252316
NM_028230

RefSeq (protein)

NP_001159828
NP_001159829
NP_001159830
NP_001159831
NP_005403

NP_001239245
NP_082506

Location (UCSC)Chr 12: 57.23 – 57.23 MbChr 10: 127.35 – 127.36 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serine hydroxymethyltransferase 2 is an enzyme that in humans is encoded by the SHMT2 gene.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000182199 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025403 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Anderson DD, Stover PJ (June 2009). "SHMT1 and SHMT2 are functionally redundant in nuclear de novo thymidylate biosynthesis". PLOS ONE. 4 (6): e5839. Bibcode:2009PLoSO...4.5839A. doi:10.1371/journal.pone.0005839. PMC 2688753. PMID 19513116.


  • v
  • t
  • e