SNTG1

Protein-coding gene in the species Homo sapiens
SNTG1
Identifiers
AliasesSNTG1, G1SYN, SYN4, syntrophin gamma 1
External IDsOMIM: 608714; MGI: 1918346; HomoloGene: 56834; GeneCards: SNTG1; OMA:SNTG1 - orthologs
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for SNTG1
Genomic location for SNTG1
Band8q11.21Start49,909,789 bp[1]
End50,796,692 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for SNTG1
Genomic location for SNTG1
Band1|1 A1-A2Start8,361,475 bp[2]
End9,299,878 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Brodmann area 23

  • primary visual cortex

  • middle temporal gyrus

  • ventricular zone

  • testicle

  • dorsolateral prefrontal cortex

  • Brodmann area 9

  • nucleus accumbens

  • prefrontal cortex

  • caudate nucleus
Top expressed in
  • spermatid

  • superior frontal gyrus

  • facial motor nucleus

  • cerebellar cortex

  • hippocampus proper

  • seminiferous tubule

  • primary motor cortex

  • mesencephalon

  • anterior horn of spinal cord

  • neural tube
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • actin binding
  • protein C-terminus binding
  • structural molecule activity
Cellular component
  • cytoplasm
  • ruffle membrane
  • syntrophin complex
  • cytoskeleton
  • nucleus
  • dystrophin-associated glycoprotein complex
Biological process
  • cell communication
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

54212

71096

Ensembl

ENSG00000147481

ENSMUSG00000025909

UniProt

Q9NSN8

Q925E1

RefSeq (mRNA)
NM_001287813
NM_001287814
NM_018967
NM_001321773
NM_001321775

NM_001321776
NM_001321777
NM_001321778

NM_001290390
NM_001290392
NM_001290393
NM_027671

RefSeq (protein)
NP_001274742
NP_001274743
NP_001308702
NP_001308704
NP_001308705

NP_001308706
NP_001308707
NP_061840
NP_001274742.1
NP_061840.1
NP_001308702.1

NP_001277319
NP_001277321
NP_001277322
NP_081947

Location (UCSC)Chr 8: 49.91 – 50.8 MbChr 1: 8.36 – 9.3 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Gamma-1-syntrophin is a protein that in humans is encoded by the SNTG1 gene.[5][6]

The protein encoded by this gene is a member of the syntrophin family. Syntrophins are cytoplasmic peripheral membrane proteins that typically contain 2 pleckstrin homology (PH) domains, a PDZ domain that bisects the first PH domain, and a C-terminal domain that mediates dystrophin binding. This gene is specifically expressed in the brain. Transcript variants for this gene have been described, but their full-length nature has not been determined.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000147481 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025909 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Piluso G, Mirabella M, Ricci E, Belsito A, Abbondanza C, Servidei S, Puca AA, Tonali P, Puca GA, Nigro V (Jun 2000). "Gamma1- and gamma2-syntrophins, two novel dystrophin-binding proteins localized in neuronal cells". J Biol Chem. 275 (21): 15851–60. doi:10.1074/jbc.M000439200. PMID 10747910.
  6. ^ a b "Entrez Gene: SNTG1 syntrophin, gamma 1".

Further reading

  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Hogan A, Shepherd L, Chabot J, et al. (2001). "Interaction of gamma 1-syntrophin with diacylglycerol kinase-zeta. Regulation of nuclear localization by PDZ interactions". J. Biol. Chem. 276 (28): 26526–33. doi:10.1074/jbc.M104156200. PMID 11352924.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Widberg CH, Bryant NJ, Girotti M, et al. (2003). "Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation". J. Biol. Chem. 278 (37): 35093–101. doi:10.1074/jbc.M304261200. PMID 12832401.
  • Buxton P, Zhang XM, Walsh B, et al. (2004). "Identification and characterization of Snapin as a ubiquitously expressed SNARE-binding protein that interacts with SNAP23 in non-neuronal cells". Biochem. J. 375 (Pt 2): 433–40. doi:10.1042/BJ20030427. PMC 1223698. PMID 12877659.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Chen Z, Hague C, Hall RA, Minneman KP (2006). "Syntrophins regulate alpha1D-adrenergic receptors through a PDZ domain-mediated interaction". J. Biol. Chem. 281 (18): 12414–20. doi:10.1074/jbc.M508651200. PMID 16533813.
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