RNH1

Protein-coding gene in the species Homo sapiens

RNH1

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
1Z7X, 1A4Y, 2BEX, 2Q4G

Identifiers

Aliases

RNH1, RAI, RNH, ribonuclease/angiogenin inhibitor 1

External IDs

OMIM: 173320; MGI: 1195456; HomoloGene: 2204; GeneCards: RNH1; OMA:RNH1 - orthologs

Gene location (Human)

Chr.	Chromosome 11 (human)^[1]

Band	11p15.5	Start	494,512 bp^[1]
Band	11p15.5	End	507,300 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)^[2]

Band	7\|7 F5	Start	140,740,239 bp^[2]
Band	7\|7 F5	End	140,752,770 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

skin of leg

skin of abdomen

ectocervix

right coronary artery

mucosa of esophagus

vagina

left coronary artery

right auricle

left uterine tube

upper lobe of left lung

Top expressed in

calvaria

gastrula

esophagus

stroma of bone marrow

skin of external ear

endothelial cell of lymphatic vessel

cervix

corneal stroma

belly cord

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	ribonuclease inhibitor activity protein binding
Cellular component	angiogenin-PRI complex extracellular exosome nucleoplasm cytoplasm cytosol
Biological process	regulation of angiogenesis mRNA catabolic process negative regulation of catalytic activity
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


6050


107702

Ensembl


ENSG00000276230 ENSG00000023191


ENSMUSG00000038650

UniProt


P13489


Q91VI7

RefSeq (mRNA)

NM_002939 NM_203383 NM_203384 NM_203385 NM_203386
NM_203387 NM_203388 NM_203389


NM_001172100 NM_001172101 NM_145135

RefSeq (protein)

NP_002930 NP_976317 NP_976318 NP_976319 NP_976320
NP_976321 NP_976322 NP_976323


NP_001165571 NP_001165572 NP_660117

Location (UCSC)

Chr 11: 0.49 – 0.51 Mb

Chr 7: 140.74 – 140.75 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Ribonuclease inhibitor is an enzyme that in humans is encoded by the RNH1 gene.^[5]

References

^ ^a ^b ^c ENSG00000023191 GRCh38: Ensembl release 89: ENSG00000276230, ENSG00000023191 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038650 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: RNH1 ribonuclease/angiogenin inhibitor 1".

Zneimer SM, Crawford D, Schneider NR, Beutler B (1991). "Mapping of the human ribonuclease inhibitor gene (RNH) to chromosome 11p15 by in situ hybridization". Genomics. 8 (1): 175–8. doi:10.1016/0888-7543(90)90242-M. PMID 2081593.
Weremowicz S, Fox EA, Morton CC, Vallee BL (1991). "The placental ribonuclease inhibitor (RNH) gene is located on chromosome subband 11p15.5". Genomics. 8 (4): 717–21. doi:10.1016/0888-7543(90)90260-2. PMID 2276743.
Lee FS, Vallee BL (1989). "Binding of placental ribonuclease inhibitor to the active site of angiogenin". Biochemistry. 28 (8): 3556–61. doi:10.1021/bi00434a061. PMID 2742853.
Bond MD, Vallee BL (1989). "Isolation of bovine angiogenin using a placental ribonuclease inhibitor binding assay". Biochemistry. 27 (17): 6282–7. doi:10.1021/bi00417a013. PMID 3064806.
Hofsteenge J, Kieffer B, Matthies R, et al. (1989). "Amino acid sequence of the ribonuclease inhibitor from porcine liver reveals the presence of leucine-rich repeats". Biochemistry. 27 (23): 8537–44. doi:10.1021/bi00423a006. PMID 3219361.
Lee FS, Fox EA, Zhou HM, et al. (1989). "Primary structure of human placental ribonuclease inhibitor". Biochemistry. 27 (23): 8545–53. doi:10.1021/bi00423a007. PMID 3219362.
Schneider R, Schneider-Scherzer E, Thurnher M, et al. (1989). "The primary structure of human ribonuclease/angiogenin inhibitor (RAI) discloses a novel highly diversified protein superfamily with a common repetitive module". EMBO J. 7 (13): 4151–6. doi:10.1002/j.1460-2075.1988.tb03310.x. PMC 455125. PMID 3243277.
Shapiro R, Vallee BL (1987). "Human placental ribonuclease inhibitor abolishes both angiogenic and ribonucleolytic activities of angiogenin". Proc. Natl. Acad. Sci. U.S.A. 84 (8): 2238–41. Bibcode:1987PNAS...84.2238S. doi:10.1073/pnas.84.8.2238. PMC 304624. PMID 3470787.
Kiyohara H, Menjo M (1984). "Ribonuclease and ribonuclease inhibitor in the human pancreas". Gastroenterol. Jpn. 18 (5): 468–73. doi:10.1007/BF02776587. PMID 6653993. S2CID 10963236.
Nadano D, Yasuda T, Takeshita H, et al. (1994). "Purification and characterization of human brain ribonuclease inhibitor". Arch. Biochem. Biophys. 312 (2): 421–8. doi:10.1006/abbi.1994.1328. PMID 8037455.
Kobe B, Deisenhofer J (1994). "Crystal structure of porcine ribonuclease inhibitor, a protein with leucine-rich repeats". Nature. 366 (6457): 751–6. doi:10.1038/366751a0. PMID 8264799. S2CID 34579479.
Papageorgiou AC, Shapiro R, Acharya KR (1997). "Molecular recognition of human angiogenin by placental ribonuclease inhibitor--an X-ray crystallographic study at 2.0 A resolution". EMBO J. 16 (17): 5162–77. doi:10.1093/emboj/16.17.5162. PMC 1170149. PMID 9311977.
Gaur D, Swaminathan S, Batra JK (2001). "Interaction of human pancreatic ribonuclease with human ribonuclease inhibitor. Generation of inhibitor-resistant cytotoxic variants". J. Biol. Chem. 276 (27): 24978–84. doi:10.1074/jbc.M102440200. PMID 11342552.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Fu P, Chen J, Tian Y, et al. (2005). "Anti-tumor effect of hematopoietic cells carrying the gene of ribonuclease inhibitor". Cancer Gene Ther. 12 (3): 268–75. doi:10.1038/sj.cgt.7700742. PMID 15592448.
Iyer S, Holloway DE, Kumar K, et al. (2005). "Molecular recognition of human eosinophil-derived neurotoxin (RNase 2) by placental ribonuclease inhibitor". J. Mol. Biol. 347 (3): 637–55. doi:10.1016/j.jmb.2005.01.035. PMID 15755456.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Johnson RJ, McCoy JG, Bingman CA, et al. (2007). "Inhibition of Human Pancreatic Ribonuclease by the Human Ribonuclease Inhibitor Protein". J. Mol. Biol. 368 (2): 434–49. doi:10.1016/j.jmb.2007.02.005. PMC 1993901. PMID 17350650.

PDB gallery

1a4y: RIBONUCLEASE INHIBITOR-ANGIOGENIN COMPLEX
1z7x: X-ray structure of human ribonuclease inhibitor complexed with ribonuclease I
2bex: CRYSTAL STRUCTURE OF PLACENTAL RIBONUCLEASE INHIBITOR IN COMPLEX WITH HUMAN EOSINOPHIL DERIVED NEUROTOXIN AT 2A RESOLUTION