RNF123

Protein-coding gene in the species Homo sapiens
RNF123
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2MA6

Identifiers
AliasesRNF123, KPC1, FP1477, ring finger protein 123
External IDsOMIM: 614472; MGI: 2148796; HomoloGene: 11112; GeneCards: RNF123; OMA:RNF123 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for RNF123
Genomic location for RNF123
Band3p21.31Start49,689,538 bp[1]
End49,721,529 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for RNF123
Genomic location for RNF123
Band9|9 F1Start107,928,733 bp[2]
End107,960,545 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • muscle of thigh

  • gastrocnemius muscle

  • vastus lateralis muscle

  • Skeletal muscle tissue of rectus abdominis

  • right lobe of liver

  • triceps brachii muscle

  • body of tongue

  • biceps brachii

  • Skeletal muscle tissue of biceps brachii

  • thoracic diaphragm
Top expressed in
  • neural layer of retina

  • saccule

  • otic vesicle

  • muscle of thigh

  • fetal liver hematopoietic progenitor cell

  • lens

  • otic placode

  • cerebellar cortex

  • skeletal muscle tissue

  • triceps brachii muscle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • metal ion binding
  • transferase activity
  • ubiquitin-protein transferase activity
Cellular component
  • cytoplasm
  • cytosol
  • nuclear membrane
Biological process
  • protein ubiquitination
  • protein deubiquitination
  • proteolysis involved in cellular protein catabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

63891

84585

Ensembl

ENSG00000164068

ENSMUSG00000041528

UniProt

Q5XPI4

Q5XPI3

RefSeq (mRNA)

NM_022064

NM_032543
NM_001311152

RefSeq (protein)

NP_071347

NP_001298081
NP_115932

Location (UCSC)Chr 3: 49.69 – 49.72 MbChr 9: 107.93 – 107.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

E3 ubiquitin-protein ligase RNF123 is an enzyme that in humans is encoded by the RNF123 gene.[5]

The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions.[5] Increased expression of the gene has been associated with laminopathies, and in degradation of chromatin associated proteins such as HP1 (Chaturvedi et al, 2012, PMID: 23077635).

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164068 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041528 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: RNF123 ring finger protein 123".

Further reading

  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
  • Kamura T, Hara T, Matsumoto M, et al. (2005). "Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase". Nat. Cell Biol. 6 (12): 1229–35. doi:10.1038/ncb1194. PMID 15531880. S2CID 12225217.
  • Kotoshiba S, Kamura T, Hara T, et al. (2005). "Molecular dissection of the interaction between p27 and Kip1 ubiquitylation-promoting complex, the ubiquitin ligase that regulates proteolysis of p27 in G1 phase". J. Biol. Chem. 280 (18): 17694–700. doi:10.1074/jbc.M500866200. PMID 15746103.
  • Hara T, Kamura T, Kotoshiba S, et al. (2005). "Role of the UBL-UBA protein KPC2 in degradation of p27 at G1 phase of the cell cycle". Mol. Cell. Biol. 25 (21): 9292–303. doi:10.1128/MCB.25.21.9292-9303.2005. PMC 1265808. PMID 16227581.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

External links


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