Pildralazine
Chemical compound
- None
- In general: ℞ (Prescription only)
- 1-[(6-Hydrazinylpyridazin-3-yl)(methyl)amino]propan-2-ol
- 64000-73-3
- 68829
- 62062
- FU2BGC781U
- DTXSID7043746
- Interactive image
- n1nc(NN)ccc1N(C)CC(O)C
InChI
- InChI=1S/C8H15N5O/c1-6(14)5-13(2)8-4-3-7(10-9)11-12-8/h3-4,6,14H,5,9H2,1-2H3,(H,10,11)
- Key:KYIAWOXNPBANEW-UHFFFAOYSA-N
Pildralazine (Atensil), also known as propyldazine or propildazine, is an antihypertensive and vasodilator.[1]
Synthesis
The reaction between 3,6-Dichloropyridazine [141-30-0] (1) and 1-(Methylamino)-2-propanol [16667-45-1] (2) gives CID:12237595 (3). Reaction with hydrazine completes the synthesis of Pidralazine (4).
References
- ^ Ganellin CR, Triggle DJ, Macdonald F (1997). Dictionary of pharmacological agents. CRC Press. p. 1603. ISBN 978-0-412-46630-4. Retrieved 25 November 2011.
- ^ Pifferi G, Parravicini F, Carpi C, Dorigotti L (July 1975). "Synthesis and antihypertensive properties of new 3-hydrazinopyridazine derivatives". Journal of Medicinal Chemistry. 18 (7): 741–746. doi:10.1021/jm00241a020. PMID 1151996.
- ^ DE2154245 idem G Pifferi, U.S. patent 3,769,278 (1973 to Isf Spa).
- v
- t
- e
Nonsympatholytic vasodilatory antihypertensives (C02)
- Nitroprusside #
- Hydralazine #
- Dihydralazine
- Endralazine
- Cadralazine
- Pildralazine
- see list
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III