POLR1A

Protein-coding gene in the species Homo sapiens
POLR1A
Identifiers
AliasesPOLR1A, A190, RPA1, RPA194, RPO1-4, RPO14, AFDCIN, polymerase (RNA) I subunit A, RNA polymerase I subunit A, RPA190
External IDsOMIM: 616404; MGI: 1096397; HomoloGene: 7033; GeneCards: POLR1A; OMA:POLR1A - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for POLR1A
Genomic location for POLR1A
Band2p11.2Start86,020,216 bp[1]
End86,106,155 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for POLR1A
Genomic location for POLR1A
Band6 C1|6 32.21 cMStart71,886,037 bp[2]
End71,961,919 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sural nerve

  • tibialis anterior muscle

  • stromal cell of endometrium

  • gonad

  • testicle

  • islet of Langerhans

  • ventricular zone

  • gastrocnemius muscle

  • muscle of thigh

  • body of uterus
Top expressed in
  • granulocyte

  • tail of embryo

  • epiblast

  • choroid plexus of fourth ventricle

  • primitive streak

  • genital tubercle

  • Epithelium of choroid plexus

  • yolk sac

  • spermatocyte

  • ventricular zone
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • transferase activity
  • DNA binding
  • nucleotidyltransferase activity
  • zinc ion binding
  • metal ion binding
  • DNA-directed 5'-3' RNA polymerase activity
  • protein binding
  • RNA polymerase I activity
  • chromatin binding
Cellular component
  • nucleoplasm
  • RNA polymerase I complex
  • nucleus
  • nucleolus
Biological process
  • termination of RNA polymerase I transcription
  • epigenetic maintenance of chromatin in transcription-competent conformation
  • transcription initiation from RNA polymerase I promoter
  • transcription, DNA-templated
  • negative regulation of protein localization to nucleolus
  • transcription elongation from RNA polymerase I promoter
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

25885

20019

Ensembl

ENSG00000068654

ENSMUSG00000049553

UniProt

O95602

O35134

RefSeq (mRNA)

NM_015425

NM_009088

RefSeq (protein)

NP_056240

NP_033114

Location (UCSC)Chr 2: 86.02 – 86.11 MbChr 6: 71.89 – 71.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

DNA-directed RNA polymerase I subunit RPA1 is an enzyme that in humans is encoded by the POLR1A gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000068654 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049553 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Seither P, Coy JF, Pouska A, Grummt I (Aug 1997). "Molecular cloning and characterization of the cDNA encoding the largest subunit of mouse RNA polymerase I". Mol Gen Genet. 255 (2): 180–6. doi:10.1007/s004380050487. PMID 9236775. S2CID 21286746.
  6. ^ "Entrez Gene: POLR1A polymerase (RNA) I polypeptide A, 194kDa".

Further reading

  • Zhu L, Perlaky L, Henning D, Valdez BC (1998). "Cloning and characterization of a new silver-stainable protein SSP29, a member of the LRR family". Biochem. Mol. Biol. Int. 42 (5): 927–35. doi:10.1080/15216549700203371. PMID 9285060. S2CID 19749385.
  • Chen HK, Pai CY, Huang JY, Yeh NH (2000). "Human Nopp140, which interacts with RNA polymerase I: implications for rRNA gene transcription and nucleolar structural organization". Mol. Cell. Biol. 19 (12): 8536–46. doi:10.1128/mcb.19.12.8536. PMC 84972. PMID 10567578.
  • Miller G, Panov KI, Friedrich JK, et al. (2001). "hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters". EMBO J. 20 (6): 1373–82. doi:10.1093/emboj/20.6.1373. PMC 145519. PMID 11250903.
  • Yuan X, Zhao J, Zentgraf H, et al. (2003). "Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter". EMBO Rep. 3 (11): 1082–7. doi:10.1093/embo-reports/kvf212. PMC 1307603. PMID 12393749.
  • Dundr M, Hoffmann-Rohrer U, Hu Q, et al. (2002). "A kinetic framework for a mammalian RNA polymerase in vivo". Science. 298 (5598): 1623–6. Bibcode:2002Sci...298.1623D. doi:10.1126/science.1076164. PMID 12446911. S2CID 36392120.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
  • Yamamoto K, Yamamoto M, Hanada K, et al. (2004). "Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription". Mol. Cell. Biol. 24 (14): 6338–49. doi:10.1128/MCB.24.14.6338-6349.2004. PMC 434256. PMID 15226435.
  • Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
  • Percipalle P, Fomproix N, Cavellán E, et al. (2006). "The chromatin remodelling complex WSTF-SNF2h interacts with nuclear myosin 1 and has a role in RNA polymerase I transcription". EMBO Rep. 7 (5): 525–30. doi:10.1038/sj.embor.7400657. PMC 1479564. PMID 16514417.


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