OR51M1

Protein-coding gene in the species Homo sapiens
OR51M1
Identifiers
AliasesOR51M1, HOR5'Beta7, OR11-40, olfactory receptor family 51 subfamily M member 1
External IDsMGI: 3030465; HomoloGene: 64935; GeneCards: OR51M1; OMA:OR51M1 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for OR51M1
Genomic location for OR51M1
Band11p15.4Start5,383,812 bp[1]
End5,393,263 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for OR51M1
Genomic location for OR51M1
Band7|7 E3Start103,578,032 bp[2]
End103,578,991 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • apex of heart
    n/a
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • olfactory receptor activity
  • signal transducer activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
Biological process
  • sensory perception of smell
  • signal transduction
  • response to stimulus
  • detection of chemical stimulus involved in sensory perception of smell
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

390059

258961

Ensembl

ENSG00000184698

ENSMUSG00000042219

UniProt

Q9H341

F8VPJ9

RefSeq (mRNA)

NM_001004756

NM_001271020
NM_146959

RefSeq (protein)

NP_001004756

NP_001257949

Location (UCSC)Chr 11: 5.38 – 5.39 MbChr 7: 103.58 – 103.58 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 51M1 is a protein that in humans is encoded by the OR51M1 gene.[5]

Function

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals.[6] The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000184698 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042219 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: OR51M1 olfactory receptor, family 51, subfamily M, member 1".
  6. ^ Knape K, Beyer A, Stary A, Buchbauer G, Wolschann P (2008). "Genomics of selected human odorant receptors". Chemical Monthly. 139 (12): 1537–1544. doi:10.1007/s00706-008-0957-6.

Further reading

  • Bulger M, van Doorninck JH, Saitoh N, et al. (1999). "Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes". Proc. Natl. Acad. Sci. U.S.A. 96 (9): 5129–34. Bibcode:1999PNAS...96.5129B. doi:10.1073/pnas.96.9.5129. PMC 21828. PMID 10220430.
  • Bulger M, Bender MA, van Doorninck JH, et al. (2001). "Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14560–5. Bibcode:2000PNAS...9714560B. doi:10.1073/pnas.97.26.14560. PMC 18958. PMID 11121057.
  • Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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Class I
(fish-like receptors)
Family 51
Family 52
Family 56
Class II
(tetrapod specific receptors)
Family 1
Family 2
Family 3
Family 4
Family 5
Family 6
Family 7
Family 8
Family 9
Family 10
Family 11
Family 12
Family 13


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