Neuropeptide B

Protein-coding gene in the species Homo sapiens
NPB
Identifiers
AliasesNPB, L7, PPL7, PPneuropeptide B
External IDsOMIM: 607996; MGI: 2387153; HomoloGene: 102151; GeneCards: NPB; OMA:NPB - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for NPB
Genomic location for NPB
Band17q25.3Start81,900,745 bp[1]
End81,902,905 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for NPB
Genomic location for NPB
Band11|11 E2Start120,499,303 bp[2]
End120,499,919 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • C1 segment

  • testicle

  • hypothalamus

  • substantia nigra

  • nucleus accumbens

  • amygdala

  • stromal cell of endometrium

  • Brodmann area 9

  • putamen

  • anterior cingulate cortex
Top expressed in
  • stomach

  • embryo

  • testicle

  • morula

  • embryo

  • right kidney

  • spermatid

  • placenta

  • urinary bladder

  • cerebellar cortex
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
  • G protein-coupled receptor binding
Cellular component
  • extracellular region
Biological process
  • neuropeptide signaling pathway
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

256933

208990

Ensembl

ENSG00000183979

ENSMUSG00000044034

UniProt

Q8NG41

Q8K4P1

RefSeq (mRNA)

NM_148896

NM_153288
NM_001347616
NM_001347617

RefSeq (protein)

NP_683694

NP_001334545
NP_001334546
NP_695020

Location (UCSC)Chr 17: 81.9 – 81.9 MbChr 11: 120.5 – 120.5 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Neuropeptide B is a short biologically active peptide whose precursor in humans is encoded by the NBP gene. Neuropeptide B acts via two G protein-coupled receptors, neuropeptide B/W receptors, called NPBW1 and NPBW2 encoded by the genes NPBWR1 and NPBWR2, respectively. Neuropeptide B is thought to be associated with the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway.[5][6] It is expressed throughout the CNS with high levels in the substantia nigra, hypothalamus, hippocampus, and spinal cord.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000183979 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044034 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Singh G, Davenport AP (Aug 2006). "Neuropeptide B and W: neurotransmitters in an emerging G-protein-coupled receptor system". British Journal of Pharmacology. 148 (8): 1033–41. doi:10.1038/sj.bjp.0706825. PMC 1752024. PMID 16847439.
  6. ^ Hondo M, Ishii M, Sakurai T (2008). "The NPB/NPW Neuropeptide System and Its Role in Regulating Energy Homeostasis, Pain, and Emotion". Orphan G Protein-Coupled Receptors and Novel Neuropeptides. Results and Problems in Cell Differentiation. Vol. 46. pp. 239–56. doi:10.1007/400_2007_056. ISBN 978-3-540-78350-3. PMID 18204824.

External links

  • Uniprot: Neuropeptide B precursor
  • v
  • t
  • e
3.6.13.6.23.6.3-4: ATPase
3.6.3
Cu++ (3.6.3.4)
Ca+ (3.6.3.8)
Na+/K+ (3.6.3.9)
H+/K+ (3.6.3.10)
  • ATP4A
Other P-type ATPase
3.6.4
3.6.5: GTPase
3.6.5.1: Heterotrimeric G protein
3.6.5.2: Small GTPase > Ras superfamily
3.6.5.3: Protein-synthesizing GTPase
3.6.5.5-6: Polymerization motors
Portal:
  • icon Biology