NAP1L1

Protein-coding gene in the species Homo sapiens
NAP1L1
Identifiers
AliasesNAP1L1, NAP1, NAP1L, NRP, nucleosome assembly protein 1 like 1
External IDsOMIM: 164060; MGI: 1855693; HomoloGene: 129218; GeneCards: NAP1L1; OMA:NAP1L1 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for NAP1L1
Genomic location for NAP1L1
Band12q21.2Start76,036,585 bp[1]
End76,084,735 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • ganglionic eminence

  • ventricular zone

  • secondary oocyte

  • ovary

  • lower lobe of lung

  • left ovary

  • right lung

  • right ovary

  • monocyte
    n/a
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • protein binding
  • RNA binding
Cellular component
  • melanosome
  • membrane
  • nucleus
  • cytoplasm
Biological process
  • DNA replication
  • nucleosome assembly
  • positive regulation of cell population proliferation
  • nervous system development
  • positive regulation of neurogenesis
  • positive regulation of neural precursor cell proliferation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

4673

53605

Ensembl

ENSG00000187109

n/a

UniProt

P55209

P28656

RefSeq (mRNA)

NM_001307924
NM_004537
NM_139207
NM_001330231
NM_001330232

NM_001146707
NM_015781
NM_001358932

RefSeq (protein)

NP_001294853
NP_001317160
NP_001317161
NP_004528
NP_631946

NP_056596
NP_001345861

Location (UCSC)Chr 12: 76.04 – 76.08 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Nucleosome assembly protein 1-like 1 is a protein that in humans is encoded by the NAP1L1 gene.[4][5]

This gene encodes a member of the nucleosome assembly protein (NAP) family. This protein participates in DNA replication and may play a role in modulating chromatin formation and contribute to the regulation of cell proliferation. Alternative splicing of this gene results in several transcript variants; however, not all have been fully described.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000187109 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Simon HU, Mills GB, Kozlowski M, Hogg D, Branch D, Ishimi Y, Siminovitch KA (Mar 1994). "Molecular characterization of hNRP, a cDNA encoding a human nucleosome-assembly-protein-I-related gene product involved in the induction of cell proliferation". Biochem J. 297 (2): 389–97. doi:10.1042/bj2970389. PMC 1137842. PMID 8297347.
  5. ^ a b "Entrez Gene: NAP1L1 nucleosome assembly protein 1-like 1".

Further reading

  • Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID 7821789.
  • Asahara H, Tartare-Deckert S, Nakagawa T, et al. (2002). "Dual roles of p300 in chromatin assembly and transcriptional activation in cooperation with nucleosome assembly protein 1 in vitro". Mol. Cell. Biol. 22 (9): 2974–83. doi:10.1128/MCB.22.9.2974-2983.2002. PMC 133748. PMID 11940655.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
  • Rehtanz M, Schmidt HM, Warthorst U, Steger G (2004). "Direct interaction between nucleosome assembly protein 1 and the papillomavirus E2 proteins involved in activation of transcription". Mol. Cell. Biol. 24 (5): 2153–68. doi:10.1128/MCB.24.5.2153-2168.2004. PMC 350572. PMID 14966293.
  • Kho Y, Kim SC, Jiang C, et al. (2004). "A tagging-via-substrate technology for detection and proteomics of farnesylated proteins". Proc. Natl. Acad. Sci. U.S.A. 101 (34): 12479–84. Bibcode:2004PNAS..10112479K. doi:10.1073/pnas.0403413101. PMC 515085. PMID 15308774.
  • Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Okuwaki M, Kato K, Shimahara H, et al. (2005). "Assembly and disassembly of nucleosome core particles containing histone variants by human nucleosome assembly protein I." Mol. Cell. Biol. 25 (23): 10639–51. doi:10.1128/MCB.25.23.10639-10651.2005. PMC 1291234. PMID 16287874.
  • Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
  • Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
  • Chi A, Valencia JC, Hu ZZ, et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". J. Proteome Res. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Eckey M, Hong W, Papaioannou M, Baniahmad A (2007). "The nucleosome assembly activity of NAP1 is enhanced by Alien". Mol. Cell. Biol. 27 (10): 3557–68. doi:10.1128/MCB.01106-06. PMC 1899999. PMID 17339334.
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