LARP4

Protein-coding gene in the species Homo sapiens

LARP4

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
2CQK, 3PKN

Identifiers

Aliases

LARP4, PP13296, La ribonucleoprotein domain family member 4

External IDs

MGI: 2443114; HomoloGene: 19173; GeneCards: LARP4; OMA:LARP4 - orthologs

Gene location (Mouse)

Chr.	Chromosome 15 (mouse)^[1]

Band	15\|15 F1	Start	99,867,946 bp^[1]
Band	15\|15 F1	End	99,914,239 bp^[1]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

n/a

Top expressed in

tail of embryo

genital tubercle

morula

superior cervical ganglion

zygote

seminal vesicula

hand

secondary oocyte

parotid gland

lacrimal gland

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding nucleic acid binding poly(A) binding RNA binding
Cellular component	membrane polysome cytoplasmic stress granule cytosolic small ribosomal subunit cytoplasm cytosol
Biological process	regulation of cell morphogenesis cytoskeleton organization positive regulation of translation protein biosynthesis
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


113251


207214

Ensembl


ENSG00000161813


ENSMUSG00000023025

UniProt


Q71RC2


Q8BWW4

RefSeq (mRNA)

NM_001170803 NM_001170804 NM_001170808 NM_052879 NM_199188
NM_199190 NM_001330415


NM_001024526 NM_001080948 NM_001284521 NM_001284522 NM_001284523

RefSeq (protein)

NP_001164274 NP_001164275 NP_001164279 NP_001317344 NP_443111
NP_954658 NP_954660 NP_001339233 NP_001339234 NP_001339235 NP_001339236 NP_001339237 NP_001339238 NP_001339239 NP_001339240 NP_001339241 NP_001339242 NP_001339243 NP_001339244 NP_001339245 NP_001339246 NP_001339247 NP_001339248 NP_001339249 NP_001339250 NP_001339251 NP_001339252 NP_001339253 NP_001339254 NP_001339255


NP_001019697 NP_001074417 NP_001271450 NP_001271451 NP_001271452

Location (UCSC)

n/a

Chr 15: 99.87 – 99.91 Mb

PubMed search

^[2]

^[3]

Wikidata

View/Edit Human

View/Edit Mouse

La-related protein 4 is a protein that in humans is encoded by the LARP4 gene.^[4]^[5] LARP4 is an RNA-binding protein which consists of a La motif (LaM), RNA recognition motif (RRM) and a putative PABP binding motif. It has been shown that LARP4 is involved in mRNA stability.^[6]

LARP4 is known to regulate cancer cell migration and invasion by altering cell shape.^[7] It is also reported to be a glioma tumor suppressor.^[8]

References

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023025 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
^ "Entrez Gene: LARP4 La ribonucleoprotein domain family, member 4".
^ Yang R, Gaidamakov SA, Xie J, Lee J, Martino L, Kozlov G, Crawford AK, Russo AN, Conte MR, Gehring K, Maraia RJ (February 2011). "La-related protein 4 binds poly(A), interacts with the poly(A)-binding protein MLLE domain via a variant PAM2w motif, and can promote mRNA stability". Molecular and Cellular Biology. 31 (3): 542–56. doi:10.1128/MCB.01162-10. PMC 3028612. PMID 21098120.
^ Seetharaman S, Flemyng E, Shen J, Conte MR, Ridley AJ (November 2016). "The RNA-binding protein LARP4 regulates cancer cell migration and invasion". Cytoskeleton. 73 (11): 680–690. doi:10.1002/cm.21336. PMC 5111583. PMID 27615744.
^ Koso H, Yi H, Sheridan P, Miyano S, Ino Y, Todo T, Watanabe S (April 2016). "Identification of RNA-Binding Protein LARP4B as a Tumor Suppressor in Glioma". Cancer Research. 76 (8): 2254–64. doi:10.1158/0008-5472.CAN-15-2308. PMID 26933087.

Stavraka C, Blagden S (October 2015). "The La-Related Proteins, a Family with Connections to Cancer". Biomolecules. 5 (4): 2701–22. doi:10.3390/biom5042701. PMC 4693254. PMID 26501340.
Kralovics R, Skoda RC (January 2005). "Molecular pathogenesis of Philadelphia chromosome negative myeloproliferative disorders". Blood Reviews. 19 (1): 1–13. doi:10.1016/j.blre.2004.02.002. PMID 15572213.
Puigdecanet E, Espinet B, Villa O, Florensa L, Besses C, Serrano S, Solé F (May 2006). "Detection of abnormalities of PRV-1, TPO, and c-MPL genes detected by fluorescence in situ hybridization in essential thrombocythemia". Cancer Genetics and Cytogenetics. 167 (1): 39–42. doi:10.1016/j.cancergencyto.2005.08.016. PMID 16682284.
Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J (November 2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proceedings of the National Academy of Sciences of the United States of America. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (April 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.