GYLTL1B

Protein-coding gene in the species Homo sapiens
LARGE2
Identifiers
AliasesLARGE2, PP5656, GYLTL1B, glycosyltransferase-like 1B, LARGE xylosyl- and glucuronyltransferase 2
External IDsOMIM: 609709; MGI: 2443769; HomoloGene: 27362; GeneCards: LARGE2; OMA:LARGE2 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for LARGE2
Genomic location for LARGE2
Band11p11.2Start45,921,621 bp[1]
End45,929,096 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for LARGE2
Genomic location for LARGE2
Band2|2 E1Start92,195,391 bp[2]
End92,205,214 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gonad

  • body of pancreas

  • skin of abdomen

  • right lobe of thyroid gland

  • left lobe of thyroid gland

  • minor salivary glands

  • skin of leg

  • placenta

  • anterior pituitary

  • skin of arm
Top expressed in
  • nasolacrimal duct

  • lip

  • parotid gland

  • tail of embryo

  • genital tubercle

  • yolk sac

  • vestibular membrane of cochlear duct

  • hair follicle

  • right kidney

  • urethra
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • transferase activity
  • catalytic activity
  • manganese ion binding
  • metal ion binding
  • xylosyltransferase activity
  • glycosyltransferase activity
  • UDP-xylosyltransferase activity
  • glucuronosyltransferase activity
  • protein binding
Cellular component
  • integral component of membrane
  • Golgi apparatus
  • membrane
  • Golgi membrane
Biological process
  • protein glycosylation
  • metabolism
  • protein O-linked mannosylation
  • muscle cell cellular homeostasis
  • protein O-linked glycosylation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

120071

228366

Ensembl

ENSG00000165905

ENSMUSG00000040434

UniProt

Q8N3Y3

Q5XPT3

RefSeq (mRNA)

NM_001300721
NM_001300722
NM_152312

NM_001166633
NM_001290773
NM_001290774
NM_001290775
NM_172670

RefSeq (protein)

NP_001287650
NP_001287651
NP_689525

NP_001160105
NP_001277702
NP_001277703
NP_001277704
NP_766258

Location (UCSC)Chr 11: 45.92 – 45.93 MbChr 2: 92.2 – 92.21 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Glycosyltransferase-like protein LARGE2 is an enzyme that in humans is encoded by the GYLTL1B gene.[5][6][7]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000165905 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040434 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Brockington M, Torelli S, Prandini P, Boito C, Dolatshad NF, Longman C, Brown SC, Muntoni F (Feb 2005). "Localization and functional analysis of the LARGE family of glycosyltransferases: significance for muscular dystrophy". Hum Mol Genet. 14 (5): 657–65. doi:10.1093/hmg/ddi062. PMID 15661757.
  6. ^ Grewal PK, McLaughlan JM, Moore CJ, Browning CA, Hewitt JE (Sep 2005). "Characterization of the LARGE family of putative glycosyltransferases associated with dystroglycanopathies". Glycobiology. 15 (10): 912–23. doi:10.1093/glycob/cwi094. PMID 15958417.
  7. ^ "Entrez Gene: GYLTL1B glycosyltransferase-like 1B".

Further reading

  • Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
  • Fujimura K, Sawaki H, Sakai T, et al. (2005). "LARGE2 facilitates the maturation of alpha-dystroglycan more effectively than LARGE". Biochem. Biophys. Res. Commun. 329 (3): 1162–71. doi:10.1016/j.bbrc.2005.02.082. PMID 15752776.
  • Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.


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