DEFA1B

Protein-coding gene in the species Homo sapiens
DEFA1B
Available structures
PDBHuman UniProt search: PDBe RCSB
List of PDB id codes

2KHT, 2PM1, 3GNY, 3H6C, 3HJ2, 3HJD, 3LO1, 3LO2, 3LO4, 3LO6, 3LO9, 3LOE, 3LVX, 4DU0, 4LB1, 4LB7, 4LBB, 4LBF

Identifiers
AliasesDEFA1B, HNP-1, HP-1, HP1, defensin alpha 1B
External IDsHomoloGene: 128756; GeneCards: DEFA1B; OMA:DEFA1B - orthologs
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for DEFA1B
Genomic location for DEFA1B
Band8p23.1Start6,996,766 bp[1]
End6,999,198 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • monocyte

  • granulocyte

  • right lung

  • spleen

  • bone marrow

  • blood

  • bone marrow cells

  • upper lobe of left lung

  • placenta

  • right lobe of liver
    n/a
More reference expression data
BioGPS
n/a
Orthologs
SpeciesHumanMouse
Entrez

728358

n/a

Ensembl

ENSG00000240247
ENSG00000285176

n/a

UniProt

P59665

n/a

RefSeq (mRNA)

NM_001302265
NM_001042500

n/a

RefSeq (protein)

NP_001035965
NP_001289194

n/a

Location (UCSC)Chr 8: 7 – 7 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Defensin, alpha 1B a human protein that is encoded by the DEFA1B gene.[3]

See also

References

  1. ^ a b c ENSG00000285176 GRCh38: Ensembl release 89: ENSG00000240247, ENSG00000285176 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Entrez Gene: defensin".

Further reading

  • Kocsis AK, Ocsovszky I, Tiszlavicz L, et al. (2009). "Helicobacter pylori induces the release of alpha-defensin by human granulocytes". Inflamm. Res. 58 (5): 241–7. doi:10.1007/s00011-008-8100-z. PMID 19169650. S2CID 29257427.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Aldred PM, Hollox EJ, Armour JA (2005). "Copy number polymorphism and expression level variation of the human alpha-defensin genes DEFA1 and DEFA3". Hum. Mol. Genet. 14 (14): 2045–52. doi:10.1093/hmg/ddi209. PMID 15944200.

External links

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Neutrophil defensin 1 (DEFA1B)


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