Coiled-coil domain containing 88b

Protein found in humans

CCDC88B

Identifiers

Aliases

CCDC88B, BRLZ, CCDC88, HKRP3, gipie, coiled-coil domain containing 88B

External IDs

OMIM: 611205; MGI: 1925567; HomoloGene: 49992; GeneCards: CCDC88B; OMA:CCDC88B - orthologs

Gene location (Human)

Chr.	Chromosome 11 (human)^[1]

Band	11q13.1	Start	64,340,204 bp^[1]
Band	11q13.1	End	64,357,534 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 19 (mouse)^[2]

Band	19\|19 A	Start	6,821,991 bp^[2]
Band	19\|19 A	End	6,835,579 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

granulocyte

cerebellar hemisphere

right hemisphere of cerebellum

spleen

appendix

monocyte

bone marrow cells

blood

mucosa of transverse colon

lymph node

Top expressed in

granulocyte

thymus

mesenteric lymph nodes

neural layer of retina

spermatocyte

spermatid

bone marrow

spleen

blood

seminiferous tubule

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	microtubule binding dynein light intermediate chain binding
Cellular component	membrane cytoplasm endoplasmic reticulum Golgi apparatus centrosome cytoskeleton
Biological process	positive regulation of T cell activation positive regulation of T cell proliferation positive regulation of cytokine production defense response to protozoan cytoskeleton-dependent intracellular transport cytoplasmic microtubule organization
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


283234


78317

Ensembl


ENSG00000168071


ENSMUSG00000047810

UniProt


A6NC98


Q4QRL3

RefSeq (mRNA)


NM_032251


NM_001081291 NM_198008

RefSeq (protein)


NP_115627


NP_001074760

Location (UCSC)

Chr 11: 64.34 – 64.36 Mb

Chr 19: 6.82 – 6.84 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Coiled-coil domain containing 88B is a protein that in humans is encoded by the CCDC88B gene. ^[5]

Function

This gene encodes a member of the hook-related protein family. Members of this family are characterized by an N-terminal potential microtubule binding domain, a central coiled-coiled and a C-terminal Hook-related domain. The encoded protein may be involved in linking organelles to microtubules. [provided by RefSeq, Oct 2009].

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000168071 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000047810 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Coiled-coil domain containing 88B". Retrieved 2018-05-27.

Matsushita E, Asai N, Enomoto A, Kawamoto Y, Kato T, Mii S, Maeda K, Shibata R, Hattori S, Hagikura M, Takahashi K, Sokabe M, Murakumo Y, Murohara T, Takahashi M (March 2011). "Protective role of Gipie, a Girdin family protein, in endoplasmic reticulum stress responses in endothelial cells". Mol. Biol. Cell. 22 (6): 736–47. doi:10.1091/mbc.E10-08-0724. PMC 3057699. PMID 21289099.
Fischer A, Schmid B, Ellinghaus D, Nothnagel M, Gaede KI, Schürmann M, Lipinski S, Rosenstiel P, Zissel G, Höhne K, Petrek M, Kolek V, Pabst S, Grohé C, Grunewald J, Ronninger M, Eklund A, Padyukov L, Gieger C, Wichmann HE, Nebel A, Franke A, Müller-Quernheim J, Hofmann S, Schreiber S (November 2012). "A novel sarcoidosis risk locus for Europeans on chromosome 11q13.1". Am. J. Respir. Crit. Care Med. 186 (9): 877–85. doi:10.1164/rccm.201204-0708OC. PMID 22837380.
Ham H, Huynh W, Schoon RA, Vale RD, Billadeau DD (April 2015). "HkRP3 is a microtubule-binding protein regulating lytic granule clustering and NK cell killing". J. Immunol. 194 (8): 3984–96. doi:10.4049/jimmunol.1402897. PMC 4390494. PMID 25762780.