CANT1

Protein-coding gene in the species Homo sapiens

CANT1

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
1S18, 1S1D, 2H2N, 2H2U

Identifiers

Aliases

CANT1, DBQD, SCAN-1, SCAN1, SHAPY, DBQD1, calcium activated nucleotidase 1, EDM7

External IDs

OMIM: 613165; MGI: 1923275; HomoloGene: 69460; GeneCards: CANT1; OMA:CANT1 - orthologs

Gene location (Human)

Chr.	Chromosome 17 (human)^[1]

Band	17q25.3	Start	78,991,716 bp^[1]
Band	17q25.3	End	79,009,867 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)^[2]

Band	11 E2\|11 83.15 cM	Start	118,297,115 bp^[2]
Band	11 E2\|11 83.15 cM	End	118,309,912 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

pancreatic ductal cell

mucosa of transverse colon

rectum

mucosa of sigmoid colon

mucosa of ileum

stromal cell of endometrium

blood

tibia

placenta

germinal epithelium

Top expressed in

pyloric antrum

gastrula

duodenum

intestinal villus

spermatocyte

large intestine

colon

epithelium of small intestine

crypt of lieberkuhn of small intestine

ileum

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	uridine-diphosphatase activity hydrolase activity signal transducer activity nucleoside-diphosphatase activity metal ion binding calcium ion binding protein homodimerization activity adenosine-diphosphatase activity guanosine-diphosphatase activity pyrophosphatase activity
Cellular component	integral component of membrane Golgi cisterna membrane Golgi apparatus extracellular exosome endoplasmic reticulum membrane endoplasmic reticulum extracellular region plasma membrane membrane specific granule lumen tertiary granule lumen ficolin-1-rich granule lumen
Biological process	positive regulation of I-kappaB kinase/NF-kappaB signaling proteoglycan biosynthetic process signal transduction neutrophil degranulation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


124583


76025

Ensembl


ENSG00000171302


ENSMUSG00000025575

UniProt


Q8WVQ1


Q8VCF1

RefSeq (mRNA)


NM_001159772 NM_001159773 NM_138793


NM_001025617 NM_001025618 NM_001267591 NM_001267592 NM_029502

RefSeq (protein)


NP_001153244 NP_001153245 NP_620148


NP_001020788 NP_001020789 NP_001254520 NP_001254521 NP_083778

Location (UCSC)

Chr 17: 78.99 – 79.01 Mb

Chr 11: 118.3 – 118.31 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

CANT1 is a gene that encodes soluble calcium-activated nucleotidase 1, an enzyme, in humans.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171302 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025575 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Failer BU, Braun N, Zimmermann H (Sep 2002). "Cloning, expression, and functional characterization of a Ca(2+)-dependent endoplasmic reticulum nucleoside diphosphatase". J Biol Chem. 277 (40): 36978–86. doi:10.1074/jbc.M201656200. PMID 12167635.
^ "Entrez Gene: CANT1 calcium activated nucleotidase 1".

External links

Human CANT1 genome location and CANT1 gene details page in the UCSC Genome Browser.

Smith TM, Hicks-Berger CA, Kim S, Kirley TL (2002). "Cloning, expression, and characterization of a soluble calcium-activated nucleotidase, a human enzyme belonging to a new family of extracellular nucleotidases". Arch. Biochem. Biophys. 406 (1): 105–15. doi:10.1016/S0003-9861(02)00420-4. PMID 12234496.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Murphy DM, Ivanenkov VV, Kirley TL (2003). "Bacterial expression and characterization of a novel, soluble, calcium-binding, and calcium-activated human nucleotidase". Biochemistry. 42 (8): 2412–21. doi:10.1021/bi026763b. PMID 12600208.
Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Dai J, Liu J, Deng Y, et al. (2004). "Structure and protein design of a human platelet function inhibitor". Cell. 116 (5): 649–59. doi:10.1016/S0092-8674(04)00172-2. PMID 15006348. S2CID 15305441.
Yang M, Kirley TL (2004). "Site-directed mutagenesis of human soluble calcium-activated nucleotidase 1 (hSCAN-1): identification of residues essential for enzyme activity and the Ca(2+)-induced conformational change". Biochemistry. 43 (28): 9185–94. doi:10.1021/bi049565o. PMID 15248776.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.

PDB gallery

1s18: Structure and protein design of human apyrase
1s1d: Structure and protein design of human apyrase
2h2n: Crystal structure of human soluble calcium-activated nucleotidase (SCAN) with calcium ion
2h2u: Crystal structure of the E130Y mutant of human soluble calcium-activated nucleotidase (SCAN) with calcium ion