Bouvardin
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IUPAC name (1S,4R,7S,10S,13S,16S,17S)-17,24-Dihydroxy-10-(4-methoxybenzyl)-4,7,9,13,15,29-hexamethyl-22-oxa-3,6,9,12,15,29-hexaazatetracyclo[14.12.2.218,21.123,27]tritriaconta-18,20,23(31),24,26,32-hexaene-2,5,8,11,14,30-hexone | |
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Chemical formula | C40H48N6O10 |
Molar mass | 772.8 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references |
Chemical compound
Bouvardin is a bicyclic hexapeptide isolated from Bouvardia ternifolia. Its chemical formula is C40H48N6O10. It is derived from the amino acid sequence Ala-Ala-Tyr-Ala-Tyr-Tyr. It has demonstrated certain anti-cancerous activities by inhibiting protein synthesis through inhibition of 80S ribosomes (eukaryotic ribosomes).[1]
References
- ^ Boger, Dale L; Patane, Michael A; Zhou, Jiacheng (1994). "Total Synthesis of Bouvardin, O-Methylbouvardin, and O-Methyl-N9-desmethylbouvardin". Journal of the American Chemical Society. 116 (19): 8544–8556. doi:10.1021/ja00098a015.
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